Aerosol Particle Transport and Deposition in Upper and Lower Airways of Infant, Child and Adult Human Lungs

Understanding transportation and deposition (TD) of aerosol particles in the human respiratory system can help clinical treatment lung diseases using medicines. The airway diameters breathing capacity lungs normally increase with age until 30. Many studies have analyzed particle TD airways. However, knowledge nanoparticle airways infants children varying inhalation flow rates is still limited literature. This study investigates (5 nm ≤ dp 500 nm) infants, children, adults. air corresponding to three ages are considered as Qin=3.22 L/min (infant), 8.09 (Child), Qin=14 (adult). It found that less deposited upper (G0–G3) than lower (G12–G15) all groups. results suggest efficiency increases decrease size due Brownian diffusion mechanism. About 3% G12–G15 for As decreased 5 nm, rate increased over 95%. present findings medical therapy by individually simulating distribution drug-aerosol patient-specific lung.